Figure EV5. Summary diagram showing MG132 effects on progerin localizations and putative involvement of caspases, splicing, and autophagy systems in progerin clearance.

In fibroblasts from HGPS patients, progerin accumulates in thread‐like PML‐NBs. MG132 treatment resulted in a caspase‐mediated reduction of SRSF‐1 levels as well as SRSF‐5 accumulation, leading to a decrease in progerin transcript levels. In parallel, MG132 at first induces nucleolar translocation of progerin and then its accumulation and degradation in autophagic vacuoles.