Table 2.
Differentially expressed proteins in schizophrenia anterior temporal lobe (ATL)
| UniProt ID | Gene name | Description | Score | Mass | Peptides | SCZ/CTRL | SD | Biological process | Molecular class | Molecular function |
|---|---|---|---|---|---|---|---|---|---|---|
| PKP2_HUMAN | PKP2 | plakophilin-2 | 76 | 97,852 | 2 | 0.05 | 5.154 | cell adhesion | unclassified | molecular function unknown |
| BIN1_HUMAN | BIN1 | Myc box-dependent-interacting protein 1 | 175 | 64,887 | 5 | 0.63 | 1.859 | cell communication and signaling | adapter molecule | receptor signaling complex scaffold activity |
| CADM1_HUMAN | CADM1 | cell adhesion molecule 1 | 102 | 48,935 | 3 | 0.44 | 4.93 | cell communication and signaling | adhesion molecule | cell adhesion molecule activity |
| CALM_HUMAN | CALM1 | calmodulin | 759 | 16,827 | 9 | 2.10 | 3.515 | cell communication and signaling | calcium binding protein | calcium ion binding |
| CDC42_HUMAN | CDC42 | cell division control protein 42 homolog | 74 | 21,696 | 2 | 4.13 | 5.878 | cell communication and signaling | GTPase | GTPase activity |
| CSRP1_HUMAN | CSRP1 | cysteine and glycine-rich protein 1 | 244 | 21,409 | 5 | 0.49 | 2.012 | cell communication and signaling | adapter molecule | receptor signaling complex scaffold activity |
| CTNB1_HUMAN | CTNNB1 | catenin beta-1 | 71 | 86,069 | 2 | 0.48 | 1.285 | cell communication and signaling | adhesion molecule | cell adhesion molecule activity |
| DPYL2_HUMAN | DPYSL2 | dihydropyrimidinase-related protein 2 | 1,892 | 62,711 | 30 | 2.40 | 2.513 | cell communication and signaling | cytoskeletal associated protein | cytoskeletal protein binding |
| PP2BA_HUMAN | PPP3CA | serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 325 | 59,335 | 5 | 1.92 | 9.805 | cell communication and signaling | serine/threonine phosphatase | protein serine/threonine phosphatase activity |
| CANB1_HUMAN | PPP3R1 | calcineurin subunit B type 1 | 76 | 19,402 | 2 | 4.30 | 9.98 | cell communication and signaling | regulatory/other subunit | Phosphatase regulator activity |
| KAP3_HUMAN | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | 157 | 46,672 | 2 | 0.47 | 1.132 | cell communication and signaling | serine/threonine kinase | protein serine/threonine kinase activity |
| SEPT7_HUMAN | SEPT7 | septin-7 | 493 | 50,933 | 11 | 2.16 | 2.939 | cell communication and signaling | cell cycle control protein | protein binding |
| SH3G2_HUMAN | SH3GL2 | endophilin-A1 | 216 | 40,108 | 4 | 1.76 | 3.614 | cell communication and signaling | unclassified | molecular function unknown |
| SIRT2_HUMAN | SIRT2 | NAD-dependent deacetylase sirtuin-2 | 220 | 43,782 | 5 | 3.94 | 8.747 | cell communication and signaling | cell cycle control protein | deacetylase activity |
| SYUB_HUMAN | SNCB | beta-synuclein | 447 | 14,279 | 6 | 2.05 | 3.512 | cell communication and signaling | unclassified | molecular function unknown |
| 1433E_HUMAN | YWHAE | 14-3-3 protein epsilon | 595 | 29,326 | 12 | 0.40 | 4.13 | cell communication and signaling | adapter molecule | receptor signaling complex scaffold activity |
| 1433G_HUMAN | YWHAG | 14-3-3 protein gamma | 1,010 | 28,456 | 18 | 0.56 | 3.229 | cell communication and signaling | adapter molecule | receptor signaling complex scaffold activity |
| 1433T_HUMAN | YWHAQ | 14-3-3 protein theta | 400 | 28,032 | 7 | 0.41 | 2.421 | cell communication and signaling | adapter molecule | receptor signaling complex scaffold activity |
| SEPT2_HUMAN | SEPT2 | septin-2 | 173 | 41,689 | 3 | 1.86 | 2.96 | cell cycle | GTPase | GTPase activity |
| DPYL1_HUMAN | CRMP1 | dihydropyrimidinase-related protein 1 | 368 | 62,487 | 6 | 3.50 | 1.543 | cell growth and/or maintenance | enzyme: hydrolase | protein binding |
| DYL1_HUMAN | DYNLL1 | dynein light chain 1, cytoplasmic | 141 | 10,530 | 4 | 1.97 | 8.851 | cell growth and/or maintenance | motor protein | motor activity |
| E41L3_HUMAN | EPB41L3 | band 4.1-like protein 3 | 473 | 121,458 | 13 | 0.56 | 7.25 | cell growth and/or maintenance | structural protein | structural molecule activity |
| FLNA_HUMAN | FLNA | filamin-A | 612 | 283,301 | 8 | 0.36 | 4.413 | cell growth and/or maintenance | anchor protein | cytoskeletal anchoring activity |
| LMNA_HUMAN | LMNA | lamin-A/C | 387 | 74,380 | 7 | 0.11 | 3.386 | cell growth and/or maintenance | structural protein | structural molecule activity |
| LMNB2_HUMAN | LMNB2 | lamin-B2 | 173 | 67,762 | 3 | 0.18 | 5.639 | cell growth and/or maintenance | structural protein | structural molecule activity |
| MAP1A_HUMAN | MAP1A | microtubule-associated protein 1A | 187 | 306,923 | 4 | 0.35 | 7.653 | cell growth and/or maintenance | cytoskeletal associated protein | cytoskeletal protein binding |
| MARE2_HUMAN | MAPRE2 | microtubule-associated protein RP/EB family member 2 | 338 | 37,236 | 6 | 2.41 | 4.902 | cell growth and/or maintenance | cytoskeletal associated protein | cytoskeletal protein binding |
| MYH9_HUMAN | MYH9 | myosin-9 | 330 | 227,646 | 4 | 0.23 | 1.904 | cell growth and/or maintenance | structural protein | structural molecule activity |
| VIME_HUMAN | VIM | vimentin | 2,238 | 53,676 | 37 | 0.35 | 5.159 | cell growth and/or maintenance | cytoskeletal protein | structural constituent of cytoskeleton |
| LEG1_HUMAN | LGALS1 | galectin-1 | 79 | 15,048 | 2 | 0.65 | 2.212 | immune response | ligand | receptor binding |
| LDHA_HUMAN | LDHA | L-lactate dehydrogenase A chain | 385 | 36,950 | 8 | 2.48 | 2.252 | metabolism; energy pathways | enzyme: dehydrogenase | catalytic activity |
| COX41_HUMAN | COX4I1 | cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 126 | 19,621 | 3 | 0.43 | 1.693 | metabolism; energy pathways | enzyme: oxidoreductase | oxidoreductase activity |
| COX5B_HUMAN | COX5B | cytochrome c oxidase subunit 5B, mitochondrial | 170 | 13,915 | 4 | 7.19 | 4.156 | metabolism; energy pathways | enzyme: oxidoreductase | oxidoreductase activity |
| GSTP1_HUMAN | GSTP1 | glutathione S-transferase P | 147 | 23,569 | 2 | 1.64 | 1.268 | metabolism; energy pathways | enzyme: glutathione transferase | glutathione transferase activity |
| NDUS8_HUMAN | NDUFS8 | NADH dehydrogenase (ubiquinone) iron-sulfur protein 8, mitochondrial | 96 | 24,203 | 2 | 1.52 | 1.993 | metabolism; energy pathways | enzyme: oxidoreductase | oxidoreductase activity |
| PDE2A_HUMAN | PDE2A | cGMP-dependent 3',5'-cyclic phosphodiesterase | 89 | 107,360 | 2 | 9.65 | 2.299 | metabolism; energy pathways | enzyme: phosphodiesterase | phosphoric diester hydrolase activity |
| ODPA_HUMAN | PDHA1 | pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 219 | 43,952 | 7 | 0.35 | 5.372 | metabolism; energy pathways | enzyme: dehydrogenase | catalytic activity |
| PGK1_HUMAN | PGK1 | phosphoglycerate kinase 1 | 510 | 44,985 | 11 | 1.86 | 6.605 | metabolism; energy pathways | enzyme: phos-photransferase | catalytic activity |
| PRDX1_HUMAN | PRDX1 | peroxiredoxin-1 | 198 | 22,324 | 4 | 3.30 | 1.57 | metabolism; energy pathways | enzyme: peroxidase | peroxidase activity |
| CALX_HUMAN | CANX | calnexin | 182 | 67,982 | 5 | 1.85 | 3.216 | protein folding | chaperone | chaperone activity |
| CH60_HUMAN | HSPD1 | 60-kDa heat shock protein, mitochondrial | 1,089 | 61,187 | 21 | 1.90 | 2.418 | protein folding; apoptosis; regulation of immune response; signal transduction | heat shock protein | heat shock protein activity |
| CALR_HUMAN | CALR | calreticulin | 197 | 48,283 | 2 | 0.31 | 1.984 | protein metabolism | chaperone | chaperone activity |
| TCPD_HUMAN | CCT4 | T-complex protein 1 subunit delta | 105 | 58,401 | 3 | 1.56 | 2.874 | protein metabolism | chaperone | chaperone activity |
| DNJC5_HUMAN | DNAJC5 | DnaJ homolog subfamily C member 5 | 93 | 22,933 | 2 | 3.89 | 5.26 | protein metabolism | chaperone | chaperone activity |
| HSP71_HUMAN | HSPA1A | heat shock 70-kDa protein 1 | 390 | 70,294 | 8 | 1.84 | 2.307 | protein metabolism | chaperone | chaperone activity |
| HSP72_HUMAN | HSPA2 | heat shock-related 70-kDa protein 2 | 485 | 70,263 | 13 | 1.91 | 2.814 | protein metabolism | heat shock protein | heat shock protein activity |
| HSP76_HUMAN | HSPA6 | heat shock 70-kDa protein 6 | 328 | 71,440 | 7 | 1.77 | 2.398 | protein metabolism | heat shock protein | heat shock protein activity |
| HSP7C_HUMAN | HSPA8 | heat shock cognate 71-kDa protein | 1,156 | 71,082 | 22 | 1.84 | 2.293 | protein metabolism | heat shock protein | heat shock protein activity |
| CH10_HUMAN | HSPE1 | 10-kDa heat shock protein | 130 | 10,925 | 3 | 2.31 | 1.134 | protein metabolism | heat shock protein | heat shock protein activity |
| PSA4_HUMAN | PSMA4 | proteasome subunit alpha type-4 | 71 | 29,750 | 3 | 0.44 | 1.528 | protein metabolism | ubiquitin proteasome system protein | ubiquitin-specific protease activity |
| SYUA_HUMAN | SNCA | alpha-synuclein | 879 | 14,451 | 12 | 1.88 | 3.76 | protein metabolism | chaperone | chaperone activity |
| EF1A1_HUMAN | EEF1A1 | elongation factor 1-alpha 1 | 312 | 50,451 | 9 | 0.58 | 2.182 | regulation of cell cycle | transcription regulatory protein | transcription regulator activity |
| H2AV_HUMAN | H2AFV | histone H2A.V | 143 | 13,501 | 2 | 0.17 | 1.264 | regulation of gene expression, epigenetic | DNA-binding protein | DNA binding |
| BASP_HUMAN | BASP1 | brain acid soluble protein 1 | 1,796 | 22,680 | 24 | 0.51 | 1.805 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | transcription regulatory protein | transcription regulator activity |
| CAND1_HUMAN | CAND1 | cullin-associated NEDD8-dissociated protein 1 | 118 | 137,999 | 2 | 1.81 | 4.005 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | transcription regulatory protein | transcription regulator activity |
| H33_HUMAN | H3F3A | histone H3.3 | 217 | 15,376 | 5 | 0.50 | 3.531 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | DNA-binding protein | DNA binding |
| H12_HUMAN | HIST1H1C | histone H1.2 | 237 | 21,352 | 3 | 0.57 | 4.622 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | DNA-binding protein | DNA binding |
| H2A1B_HUMAN | HIST1H2AB | histone H2A type 1-B/E | 249 | 14,127 | 6 | 0.38 | 2.971 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | DNA-binding protein | DNA binding |
| H2A1D_HUMAN | HIST1H2AD | histone H2A type 1-D | 226 | 14,099 | 6 | 0.33 | 1.799 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | DNA-binding protein | DNA binding |
| H2B1B_HUMAN | HIST1H2BB | histone H2B type 1-B | 190 | 13,942 | 3 | 0.41 | 5.283 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | DNA-binding protein | DNA binding |
| H2B1C_HUMAN | HIST1H2BC | histone H2B type 1-C/E/F/G/I | 165 | 13,811 | 3 | 0.43 | 1.266 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | DNA-binding protein | DNA binding |
| H4_HUMAN | HIST1H4A | histone H4 | 637 | 11,360 | 11 | 0.46 | 3.406 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | DNA-binding protein | DNA binding |
| ROA2_HUMAN | HNRNPA2B1 | heterogeneous nuclear ribonucleoproteins A2/B1 | 452 | 37,464 | 7 | 0.16 | 3.769 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | ribonucleoprotein | transcription factor binding |
| HNRPC_HUMAN | HNRNPC | heterogeneous nuclear ribonucleoproteins C1/C2 | 223 | 33,707 | 2 | 0.24 | 1.52 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | RNA-binding protein | RNA binding |
| HNRH1_HUMAN | HNRNPH1 | heterogeneous nuclear ribonucleoprotein H | 269 | 49,484 | 4 | 0.18 | 2.678 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | ribonucleoprotein | ribonucleoprotein |
| HNRH2_HUMAN | HNRNPH2 | heterogeneous nuclear ribonucleoprotein H2 | 293 | 49,517 | 3 | 0.17 | 2.343 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | ribonucleoprotein | RNA binding |
| HNRPK_HUMAN | HNRNPK | heterogeneous nuclear ribonucleoprotein K | 225 | 51,230 | 4 | 0.31 | 3.12 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | ribonucleoprotein | ribonucleoprotein |
| HNRPU_HUMAN | HNRNPU | heterogeneous nuclear ribonucleoprotein U | 114 | 91,198 | 3 | 0.41 | 1.193 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | ribonucleoprotein | RNA binding |
| MATR3_HUMAN | MATR3 | matrin-3 | 125 | 95,078 | 2 | 0.37 | 1.661 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | RNA-binding protein | RNA binding |
| NONO_HUMAN | NONO | non-POU domain-containing octamer-binding protein | 116 | 54,311 | 2 | 0.20 | 1.072 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | RNA-binding protein | RNA binding |
| PURA_HUMAN | PURA | transcriptional activator protein Pur-alpha | 157 | 35,003 | 2 | 0.41 | 2.617 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | transcription factor | transcription factor activity |
| SFRS3_HUMAN | SFRS3 | splicing factor, arginine/serine-rich 3 | 81 | 19,546 | 2 | 0.35 | 1.529 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | RNA-binding protein | RNA binding |
| SSBP_HUMAN | SSBP1 | single-stranded DNA-binding protein, mitochondrial | 92 | 17,249 | 2 | 7.35 | 3.86 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | DNA-binding protein | DNA binding |
| SEPT5_HUMAN | SEPT5 | septin-5 | 327 | 43,206 | 11 | 0.52 | 5.659 | signal transduction | GTPase | GTP binding |
| ANXA2_HUMAN | ANXA2 | annexin A2 | 319 | 38,808 | 5 | 0.46 | 6.797 | signal transduction; cell communication | calcium-binding protein | calcium ion binding |
| EAA1_HUMAN | SLC1A3 | excitatory amino acid transporter 1 | 307 | 59,705 | 6 | 0.22 | 6.411 | transport | transport/cargo protein | transporter activity |
Score, MASCOT Identification Score (cutoff for this dataset: 55); mass, the molecular mass of the protein (Da); peptides, number of identified peptides by mass spectrometry; SCZ/CTRL, fold change ratio between schizophrenia and control samples; SD, standard deviation among quantified peptides.