Table 3.
Differentially expressed proteins in schizophrenia CC
| UniProt ID | Gene name | Protein name | Score | Mass | Peptides | SCZ/CTRL | SD | Biological process | Molecular class | Molecular function |
|---|---|---|---|---|---|---|---|---|---|---|
| ARF1_HUMAN | ARF1 | ADP-ribosylation factor 1 | 298 | 20,741 | 7 | 4.26 | 5.333 | cell communication and signaling | GTPase | GTPase activity |
| BASP_HUMAN | BASP1 | brain acid soluble protein 1 | 766 | 22,680 | 14 | 5.96 | 3.633 | reg. nucleic acid metabolism | transcription regulatory protein | transcription regulator activity |
| CALM_HUMAN | CALM1 | calmodulin | 349 | 16,827 | 7 | 2.63 | 1.817 | cell communication and signaling | calcium-binding protein | calcium ion binding |
| KCC2A_HUMAN | CAMK2A | calcium/calmodulin-dependent protein kinase type II subunit alpha | 469 | 54,566 | 10 | 3.08 | 8.707 | cell communication and signaling | serine/threonine kinase | protein serine/threonine kinase activity |
| KCC2B_HUMAN | CAMK2B | calcium/calmodulin-dependent protein kinase type II subunit beta | 180 | 73,593 | 4 | 5.90 | 5.656 | cell communication and signaling | serine/threonine kinase | protein serine/threonine kinase activity |
| KCC2G_HUMAN | CAMK2G | calcium/calmodulin-dependent protein kinase type II subunit gamma | 195 | 63,311 | 4 | 7.19 | 4.726 | cell communication and signaling | serine/threonine kinase | protein serine/threonine kinase activity |
| CDC42_HUMAN | CDC42 | cell division control protein 42 homolog | 85 | 21,696 | 2 | 2.09 | 3.534 | cell communication and signaling | GTPase | GTPase activity |
| COF1_HUMAN | CFL1 | cofilin-1 | 192 | 18,719 | 6 | 5.54 | 4.899 | cell growth and maintenance | cytoskeletal associated protein | cytoskeletal protein binding |
| CSRP1_HUMAN | CSRP1 | cysteine and glycine-rich protein 1 | 458 | 21,409 | 7 | 4.07 | 5.108 | cell communication and signaling | adapter molecule | receptor signaling complex scaffold activity |
| DPYL2_HUMAN | DPYSL2 | dihydropyrimidinase-related protein 2 | 1,679 | 62,711 | 25 | 7.07 | 5.889 | cell communication and signaling | cytoskeletal associated protein | cytoskeletal protein binding |
| H2AV_HUMAN | H2AFV | histone H2A.V | 422 | 13,501 | 5 | 0.42 | 2.387 | reg. nucleic acid metabolism | DNA-binding protein | DNA binding |
| H14_HUMAN | HIST1H1E | histone H1.4 | 513 | 21,852 | 11 | 0.12 | 3.04 | reg. nucleic acid metabolism | DNA-binding protein | DNA binding |
| H31_HUMAN | HIST1H3A | histone H3.1 | 353 | 15,509 | 7 | 0.17 | 8.548 | reg. nucleic acid metabolism | DNA-binding protein | DNA binding |
| H4_HUMAN | HIST1H4A | histone H4 | 979 | 11,360 | 13 | 0.19 | 3.693 | reg. nucleic acid metabolism | DNA-binding protein | DNA binding |
| HMGB1_HUMAN | HMGB1 | high-mobility group protein B1 | 315 | 25,049 | 3 | 0.01 | 5.9 | reg. nucleic acid metabolism | DNA-binding protein | DNA binding |
| ROA2_HUMAN | HNRNPA2B1 | heterogeneous nuclear ribonucleoproteins A2/B1 | 325 | 37,464 | 6 | 0.43 | 5.195 | reg. nucleic acid metabolism | Ribonucleoprotein | Transcription factor binding |
| HNRPR_HUMAN | HNRNPR | heterogeneous nuclear ribonucleoprotein R | 106 | 71,184 | 2 | 0.03 | 1.653 | reg. nucleic acid metabolism | RNA-binding protein | RNA binding |
| HNRPU_HUMAN | HNRNPU | heterogeneous nuclear ribonucleoprotein U | 373 | 91,198 | 8 | 0.19 | 5.492 | reg. nucleic acid metabolism | ribonucleoprotein | RNA binding |
| HP1B3_HUMAN | HP1BP3 | heterochromatin protein 1-binding protein 3 | 78 | 61,454 | 2 | 3.40 | 5.984 | reg. nucleic acid metabolism | DNA-binding protein | DNA binding |
| HSP71_HUMAN | HSPA1A | heat shock 70-kDa protein 1A/1B | 310 | 70,294 | 5 | 1.58 | 1.484 | protein metabolism | chaperone | chaperone activity |
| LMNA_HUMAN | LMNA | prelamin-A/C | 1,140 | 74,380 | 24 | 0.41 | 7.189 | cell growth and maintenance | structural protein | structural molecule activity |
| LMNB2_HUMAN | LMNB2 | lamin-B2 | 207 | 67,762 | 2 | 0.05 | 2.067 | cell growth and maintenance | structural protein | structural molecule activity |
| NPM_HUMAN | NPM1 | nucleophosmin | 172 | 32,726 | 2 | 6.64 | 1.167 | protein metabolism | chaperone | chaperone activity |
| PTMA_HUMAN | PTMA | prothymosin alpha | 177 | 12,196 | 3 | 10.62 | 2.334 | cell growth and maintenance | unclassified | molecular function unknown |
| S100B_HUMAN | S100B | protein S100-B | 290 | 10,820 | 3 | 0.30 | 1.203 | cell communication and signaling | calcium-binding protein | calcium ion binding |
Score, MASCOT Identification Score (cutoff for this dataset: 55); mass, the molecular mass of the protein (Da); peptides, number of identified peptides by mass spectrometry; SCZ/CTRL, fold change ratio between schizophrenia and control samples; SD, standard deviation among quantified peptides.