Table 2.
Risk factors for treatment refusal in lung cancer
| Age adjusted analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | P | Odds ratio | 95% CI | P | |
| Age | 1.12 | 1.09–1.14 | <0.001 | 1.10 | 1.07–1.13 | <0.001 |
| Gender | ||||||
| Female | Reference | |||||
| Male | 1.03 | 0.67–1.60 | 0.880 | |||
| Smoking (pack year) | ||||||
| <10 | Reference | |||||
| ≥10 | 1.21 | 0.80–1.83 | 0.359 | |||
| Alcohol | ||||||
| Non‐drinker | Reference | |||||
| Drinker | 1.07 | 0.71–1.64 | 0.738 | |||
| Occupation | ||||||
| Unemployed | Reference | |||||
| Employed | 0.83 | 0.43–1.60 | 0.581 | |||
| Religion | ||||||
| Absent | Reference | |||||
| Present | 0.88 | 0.58–1.32 | 0.532 | |||
| Relationship status | ||||||
| None | Reference | |||||
| In a relationship | 0.87 | 0.54–1.42 | 0.581 | |||
| Offspring | ||||||
| 0 | Reference | |||||
| 1–2 | 1.28 | 0.46–3.58 | 0.638 | |||
| ≥3 | 1.14 | 0.41–3.14 | 0.800 | |||
| Education | ||||||
| More than high school | Reference | Reference | ||||
| Less than high school | 1.62 | 1.05–2.51 | 0.030 | 1.95 | 1.20–3.17 | 0.007 |
| History of surgery | ||||||
| Present | Reference | Reference | ||||
| Absent | 1.92 | 1.25–2.94 | 0.003 | 2.29 | 1.42–3.69 | 0.001 |
| Personal history of cancer | ||||||
| Present | Reference | |||||
| Absent | 1.71 | 0.89–3.29 | 0.108 | |||
| Cancer family | ||||||
| Absent | Reference | |||||
| Present | 0.73 | 0.24–2.23 | 0.583 | |||
| BMI | ||||||
| 18.5–25 | Reference | Reference | ||||
| >25 | 1.06 | 0.63–1.78 | 0.839 | 1.38 | 0.77–2.46 | 0.278 |
| <18.5 | 3.36 | 1.86–6.07 | <0.001 | 2.49 | 1.32–4.71 | 0.005 |
| Pathology | ||||||
| Small cell carcinoma | Reference | |||||
| Non‐small cell carcinoma | 0.68 | 0.38–1.20 | 0.181 | |||
| Chest symptoms | ||||||
| Absent | Reference | |||||
| Present | 1.43 | 0.92–2.21 | 0.113 | |||
| Systemic symptoms | ||||||
| Absent | Reference | Reference | ||||
| Present | 2.52 | 1.67–3.80 | <0.001 | 1.26 | 0.76–2.10 | 0.377 |
| CCI, age adjusted | 1.17 | 1.11–1.23 | <0.001 | 1.02 | 0.95–1.10 | 0.511 |
| ECOG | ||||||
| 0 | Reference | Reference | ||||
| 1 | 1.87 | 0.99–3.52 | 0.052 | 1.42 | 0.73–2.77 | 0.301 |
| 2 | 3.64 | 1.76–7.55 | 0.001 | 2.37 | 1.07–5.23 | 0.033 |
| 3–4 | 8.07 | 4.08–15.94 | <0.001 | 5.02 | 2.32–10.84 | <0.001 |
| TNM | ||||||
| Stage 1 | Reference | Reference | ||||
| Stage 2 | 1.63 | 0.50–5.32 | 0.422 | 1.18 | 0.33–4.27 | 0.804 |
| Stage 3 | 2.92 | 1.21–7.01 | 0.017 | 1.86 | 0.72–4.82 | 0.202 |
| Stage 4 | 4.45 | 2.01–9.59 | <0.001 | 2.21 | 0.92–5.34 | 0.078 |
BMI, body mass index; CCI, Charlson comorbidity index; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; TNM, tumor node metastasis.