Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 4;3:17043. doi: 10.1038/cddiscovery.2017.43

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

TRF2 shuttles to the nucleolus and induces the DNA damage response. (a) HepG2 cells were transfected with control or NOLC1-targeting siRNA for 72 h. Chromatin extracts were subjected to western blot analysis with the indicated antibodies. (b) The levels of 53BP1 and rH2AX were determined by western blotting in HepG2 cells transfected with Flag-NOLC1 or both Flag-NOLC1 and GFP-TRF2. (c and d) 53BP1 foci (green) and NOLC1 (red) in nuclei of 293T and HepG2 cells were visualized with the indicated antibodies after NOLC1 knockdown or overexpression. Nuclei were visualized by DAPI staining.