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A proposed working model to explain how NOLC1 functions in the nucleolar accumulation of TRF2. Under normal conditions, the levels of TRF2 in the nucleolus and at telomeres are strictly balanced. When NOLC1 expression increases, TRF2 accumulates in the nucleolus and disassociates from telomeres, leading to the DNA damage response at telomeres, which promotes apoptosis and cell cycle arrest.
