Table 1.
Theacrine Pharmacokinetics
| Parametera | Condition 1b | Condition 2c | Condition 4d |
|---|---|---|---|
| Cmax (ng/mL) | 34.1 ± 38.9 | 25.6 ± 5.5 | 38.6 ± 16.6 |
| Tmax (hours) | 1.8 (0.5–6.0) | 1.8 (1.0–4.0) | 1.0 (0.3–2.0) |
| t1/2 (hours) | 16.5 ± 2.4 | 26.1 ± 13.7 | 29.2 ± 25.3 |
| AUC (h × ng/mL/mg) | 809 ± 923 | 736 ± 312 | 1242 ± 1129 |
| CL/F (L/h) | 2.0 ± 0.9 | 1.6 ± 0.5 | 1.2 ± 0.6 |
| Vd/F (L) | 48.1 ± 23.5 | 51 ± 8.5 | 35.4 ± 12.4 |
| MRT (hours) | 24.9 ± 3.5 | 36.8 ± 18.9 | 41.7 ± 38.8 |
a
Tmax values are expressed as median (range). All other values are expressed as mean ± SD and represent dose-adjusted pharmacokinetic parameters.
b
Theacrine 25 mg.
c
Theacrine 125 mg.
d
Theacrine 125 mg + Caffeine 150 mg.
AUC, area under the curve; SD, standard deviation.