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Catalytic function of recombinant cytochrome P450_5437 candidate (5437). A, B) Extracted ion chromatograms showing the in vitro catalytic activity of 5437 (CPR/5437) using vinorine (A) and vomilenine (B) as substrate, compared with the negative control (CPR). C) Only the microsomal preparations containing recombinant 5437 with vinorine (m/z 335) yield two reactions products. Vomilenine occurs as C‐21 epimers in solution. CPR=cytochrome P450 reductase.
