Table I.
Clinical data of patients with acute hepatitis and acute liver failure.
| Variable | Acute hepatitis (n=27) | Acute liver failure (n=11) | P-value |
|---|---|---|---|
| Age (years) | 47.9±19.1 | 59.8±18.0 | NS |
| Sex (male/female) | 14/13 | 6/5 | NS |
| Serum total bilirubin (mg/dl) | 6.3±7.0 | 11.0±7.1 | P<0.05 |
| Aspartate aminotransferase (IU/l) | 515.8±520.8 | 2,253.1±2,572.4 | P<0.05 |
| Alanine aminotransferase (IU/l) | 717.1±856.4 | 1,642.6±1,515.7 | P<0.05 |
| Lactate dehydrogenase (IU/l) | 824.7±1,784.9 | 3,490.7±5,212.4 | P<0.05 |
| alkaline phosphatase (IU/l) | 499.6±630.0 | 1,093.3±1,693.5 | NS |
| γ-glutamyl transpeptidase (IU/l) | 213.7±261.1 | 106.9±82.8 | NS |
| Cholinesterase (IU/l) | 234.1±80.1 | 149.0±55.8 | NS |
| Serum albumin (g/dl) | 3.7±0.7 | 3.4±0.9 | P<0.05 |
| Blood urea nitrogen (mg/dl) | 13.2±12.1 | 43.0±38.9 | P<0.05 |
| Serum creatinine (mg/dl) | 0.8±0.5 | 1.7±1.2 | P<0.05 |
| Prothrombin time (%) | 86.6±24.8 | 35.5±21.9 | P<0.05 |
| Fibrin/fibrinogen degradation products (µg/ml) | 29.1±23.5 | 3.5±2.5 | P<0.05 |
| White blood cell count (/mm3) | 6,018.3±2,575.4 | 11,444.4±5,789.0 | P<0.05 |
| Hemoglobin (g/dl) | 12.7±2.2 | 11.2±1.9 | NS |
| Platelet count (×104/mm3) | 22.0±9.0 | 10.9±11.4 | P<0.05 |
| Hepatic encephalopathy (grade II–III) | 0 | 11 | P<0.05 |
| Renal failure/heart failure/ascites/sepsis/DIC | 0/0/0/0/1 | 4/3/4/4/6 | |
| UL-VWFM positive | 0 | 4 | P<0.05 |
| Outcome (alive/dead) | 27/0 | 2/9 | P<0.05 |
Data are expressed as means ± standard deviation. NS, not significant; UL-VWFM, unusually large von Willebrand factor multimers; DIC, disseminated intravascular coagulation.