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. 2017 Sep 1;5:e3703. doi: 10.7717/peerj.3703

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©2017 Delannée et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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The metabolism of MeIQx is composed of metabolites involved in the detoxification pathways (printed in green) and components of the bioactivation pathway (printed in orange and red). Full chemical names: MeIQx, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; HONH-MeIQx, 2-(hydroxyamino)-3,8-dimethylimidazo[4,5-f]quinoxaline; MeIQx-N²-SO3H, N²-(3,8-dimethylimidazo[4,5-f]quinoxalin-2-yl)sulfamic acid; MeIQx-N²-Gl, N²- (β-1-glucosiduronyl)-2-amino-3,8-dimethylimidazo- [4,5-f]quinoxaline; 8-CH2OH-IQx, 2-amino-8-(hydroxymethyl)-3-meth-ylimidazo[4,5-f]quinoxaline; IQx-8-COOH, 2-amino-3-methyl-imidazo[4,5-f]quinoxaline-8-carboxylic acid; HON-MeIQx-N²-Gl, N²-(β-1-glucosiduronyl)-2-(hydroxyamino)-3,8-dimethylimidazo[4,f-f]quinoxaline; 7-oxo-MeIQx, 2-amino-3,8-dimethyl-6-hydro-7H-imidazo[4,5-f]quinoxalin-7-one; N-desmethyl-7-oxo-MeIQx, 2-amino-6-hydro-8-methyl-7H-imidazo[4,5-f]quinoxalin-7-one.