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. Author manuscript; available in PMC: 2018 Aug 16.
Published in final edited form as: Neuron. 2017 Aug 16;95(4):817–833.e4. doi: 10.1016/j.neuron.2017.07.037

Figure 3. OPN/IGF1 Treatment Improves Precision Performance after Spinal Cord T10 Lateral Hemisection.

Figure 3

(A) Schematic diagram of the experimental timeline. Wild type mice received baseline behavioral measurement at P56, T10 spinal cord lateral hemisection at P60, bilateral cortical injection of AAV-PLAP, AAV-OPN, AAV-IGF1 or AAV-OPN/IGF1 at P61, and biweekly behavioral measurement from P62–P145 before terminal histological analysis.

(B–E) Performance on irregular ladder walking of the hindlimb from the intact (B, C) and denervated (D, E) sides in AAV-PLAP, AAV-OPN, AAV-IGF1, and AAV-OPN/IGF1 treated animals. C and E: Hindpaw placement categories (breakdown of miss, slip, and hit) on irregular ladder walking. **: p < 0.01 and p < 0.05, respectively. Repeated measures ANOVA followed by post hoc Bonferroni correction. n = 13, 9, 8, and 12 for AAV-PLAP, AAV-OPN, AAV-IGF1, and AAV-OPN/IGF1 treated groups respectively. Hit, miss, and slip in (C) and (E) represent three categories of hindpaw placement on the rungs during walking across the ladder.