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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Nat Rev Microbiol. 2017 Feb 27;15(4):217–231. doi: 10.1038/nrmicro.2016.193

Figure 4. Phenotypic approaches to discover antitrypanosomatid compounds.

Figure 4

Various lifecycle stages can be used for the purpose of hit discovery that range from insect forms to host-stage forms in animal models. The different technologies that can be used for phenotypic assays depend on the parasite form and stage and have specific advantages and disadvantages. Examples of compounds whose antitrypanosomal activity was detected using insect forms, in vitro host-stage forms and animal models are shown.