Fig. 1.

Upregulation of PKR following cartilage inflammation. A. Representative image of cartilage from patient with total knee replacement showing non-damaged, mid-damaged and damaged regions; Protein expression (B) and ratio (C) of p-PKR to total PKR; (D) Kinase activity of p-PKR from three different regions; protein expression (E) and ratio (F) of p-PKR to total PKR after exogenous administration of TNF-α for 12 h in human chondrocytes. (n = 3; * p < .05 compared to non-damaged cartilage or control group).