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. 2017 Jul 14;292(35):14334–14348. doi: 10.1074/jbc.M117.794040

Figure 8.

Figure 8.

The model shows that DNRX regulates SV aggregation and release via presynaptic F-actin by modulating Scribble–DPix. Presynaptic DNRX interacts with Scribble–DPix to regulate the activity of Rac1, the activated Rac1 (Rac1-GTP) then affects actin polymerization to finally modulate the SVs localization and release.