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. 2017 Jul 6;292(35):14587–14602. doi: 10.1074/jbc.M117.774893

Figure 1.

Figure 1.

Aβ40(42), IAPP, and synthetic IAPP mutants (left, short names); C-terminal amides and Cys2–Cys7 disulfide bridge not shown. Similar/identical residues between Aβ and IAPP are underlined (7). Previously identified “hot segments” of IAPP self-assembly and its hetero-assembly with Aβ are in boldface type (12), and introduced Ala substituents are shown in red.