Figure 8.

Model for noncanonical microtubule interaction by Cin8 motors. A, Cin8 on the canonical site is shown in purple. Tubulin dimers shown in gray make up the microtubule lattice. Top down view is shown at the top, and side view shown at the bottom. B, monomers of Cin8 on the canonical and noncanonical sites are shown in purple and salmon, respectively. The salmon Cin8 head is smaller than the purple Cin8 head to denote an alternative binding orientation for the Cin8 bound to the noncanonical microtubule-binding site via loop L8. C, dimers of Cin8 on the canonical microtubule-binding site are shown as purple and magenta and on the noncanonical binding site as salmon and red.