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. 2017 May 31;313(2):C207–C218. doi: 10.1152/ajpcell.00241.2016

Fig. 1.

Fig. 1.

Chronic hypoxia altered ET-1-induced contractility in fetal MCAs. The ETA receptor antagonist (PD-156707) caused a right shift in the ET-1 concentration-response relation and significantly decreased pD2 in both normoxic (FN) and hypoxic (FH) fetal MCAs. Untreated FH MCAs exhibited a higher Emax than FN MCAs. Additionally, PD-156707 treatment decreased Emax in FH but not FN MCAs. Values shown represent means ± SE for n = 7–11 (FN) and n = 5–7 (FH). ‡P < 0.05, FN vs. FH. *P < 0.05, control vs. PD-156707.