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Effect of a selective FFA2 antagonist on IND + PA1-induced duodenal lesions. PA1 was given at 1 mg/kg ig. The effect of cotreatment with the FFA2 antagonist GLPG-0974 (0.1 or 1 mg/kg) on IND + PA1-induced intestinal lesions was examined. A: duodenal ulcer index. B: nonduodenal intestinal ulcer index. C: overall ulcer index. Each column is expressed as the mean ± SE (n = 6). P < 0.05 vs. IND alone group (*), IND + PA1 + veh group (†), and IND + PA1 + GLPG-0974 (0.1 mg/kg) group (‡).
