Fig. 7.

Effect of the FFA2 antagonist on the stimulatory effects of PA1. The duodenal loop was perfused with PA1 (1 µM) with or without GLPG-0974 (0.1–10 µM) in vivo. A: PA1-induced augmented $\mathrm{HC}{\mathrm{O}}_{\mathrm{3}}^{\mathrm{-}}$ secretion was dose dependently inhibited by coperfusion with GLPG-0974. B: GLPG-0974 dose dependently inhibited PA1-induced augmented 5-HT concentration in PV. Each data point is expressed as the mean ± SE (n = 5 or 6). *P < 0.05 vs. PA1 group.