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Arg2 deficiency or arginase inhibition increased kidney PGC-1α mRNA after IRI. Quantitative RT-PCR was performed on kidney RNA for PGC-1α expression in WT and Arg2−/− mice (A) or BEC-treated mice (B) following ischemia. Values are means ± SE for n = 6 mice in each group. *P < 0.05 vs. sham. #P < 0.05 vs. vehicle-treated or WT IRI.
