Table 1.
Body weight and blood pressure in experiment group
| Sham |
IRI |
|||
|---|---|---|---|---|
| BW, g | SBP, mmHg | BW, g | SBP, mmHg | |
| WT vehicle | 23.7 ± 0.4 | 152 ± 9 | 23.2 ± 0.5 | 136 ± 8 |
| WT BEC | 23.2 ± 0.6 | 164 ± 10 | 24.7 ± 0.6 | 156 ± 13 |
| Arg2+/+ | 23.6 ± 0.5 | 140 ± 12 | 24 ± 0.6 | 131 ± 16 |
| Arg2−/− | 23.6 ± 0.4 | 141 ± 9 | 23.8 ± 0.4 | 140 ± 14 |
| NOS3−/− vehicle | 23.6 ± 0.5 | 167 ± 5 | 23.8 ± 0.6 | 195 ± 7* |
| NOS3−/− BEC | 23.8 ± 0.4 | 165 ± 4 | 23.6 ± 0.4 | 195 ± 5* |
Values are means ± SE; n = 5 or 6 mice/group. WT, wild type; Arg2, arginase-2; NOS3, endothelial nitric oxide synthase; BW, body weight; SBP, systolic blood pressure; IRI, ischemia-reperfusion injury.
*
P < 0.01 vs. sham.