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. 2017 Mar 22;313(2):F282–F290. doi: 10.1152/ajprenal.00579.2016

Fig. 2.

Fig. 2.

Mitochondrial oxygen consumption rates (OCR) in STN A: state 3. Increased mitochondrial OCR in STN with the addition of ADP in the presence of oxidizable complex I substrates (pyruvate and glutamate) and complex II substrate (succinate) after inhibition of complex I by rotenone. *P = 0.008, #P = 0.007, and $P = 0.049 for STN vs. control (Con); n = 8 per group. B: state 4. Increased mitochondrial OCR in STN with the addition of ATP synthase inhibitor oligomycin in the presence of oxidizable complex I substrates (pyruvate and glutamate) and complex II substrate (succinate) after inhibition of complex I by rotenone. *P = 0.015, #P = 0.004, and $P = 0.08 for STN vs. control (Con); n = 8 per group. C: state 3u: Increased mitochondrial OCR in STN with the addition of uncoupler, FCCP, in the presence of oxidizable complex I substrates (pyruvate and glutamate) and complex II substrate (succinate) after inhibition of complex I by rotenone. *P < 0.001, #P < 0.001, and $P = 0.05 for STN vs. control (Con); n = 8 per group.