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Impact of hypoxia inducible factor-1α (HIF-1α) activation on mitochondrial OCR. Mitochondrial OCR significantly reduced in both controls and STN with HIF-1α activation with DMOG in state 3 and state 3u in the presence of complex II substrate (succinate) after inhibition of complex I by rotenone. For state 3 ANOVA P < 0.001 and state 3u ANOVA P = 0.002, post hoc pairwise comparisons: *P < 0.05 STN vs. Con, #P < 0.05 ConD vs. Con, and **P < 0.05 STN vs. STND; n = 4–8 per group.
