Table 1.

Border zone model with individual effects of RyR2 activation via β-AR stimulation (with all other β-AR stimulation downstream effects disabled)

RyR2_τ Change	RyR2_Amp Change	RyR2_leak Increase	APD Alternans Amplitude, ms	Release Integral, mmol/l JSR volume
BZ model without β-AR stimulation			20.13	8.62
True	True	True	0.32	7.69
True	True	False	0.35	8.00
True	False	True	0.19	8.02
True	False	False	0.39	8.32
False	True	True	0.49	8.18
False	True	False	0.37	8.54
False	False	True	14.05	8.43

The sarcoplasmic reticulum (SR) Ca²⁺ release integral is a sum of the Ca²⁺-induced Ca²⁺ release flux and the junctional SR (JSR) leak over two beats. True/false indicates whether or not the given effect is active or not. RyR2, type 2 ryanodine receptor; β-AR, β-adrenergic receptor; RyR2_τ, RyR2 time constant; RyR2_Amp, RyR2 amplitude of SR Ca²⁺ release; APD, action potential duration.