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. 2017 May 26;313(2):H392–H407. doi: 10.1152/ajpheart.00124.2017

Fig. 5.

Fig. 5.

Ventricular systolic and diastolic function. At the end of the study, EF (A), slope of the end-systolic pressure-volume relationship (ESPVR; B), preload recruitable stroke work (PRSW; C), and peak rate of increase in LV pressure (+dP/dt; D) did not differ across groups. The passive stiffness constant (β), derived from the end-diastolic pressure-volume relationship (EDPVR; E), varied across groups and was steeper in 10-Gy (P = 0.0008) and 20-Gy (P = 0.0001) rats than in control rats and steeper in 20-Gy rats than in 10-Gy rats (P = 0.0001). The time constant of isovolumic relaxation (τ; F) was higher in radiated rats than in control rats, consistent with impaired relaxation. Filling pressures [central venous pressure (CVP) and LV end-diastolic pressure (LVEDP), G] and MCFP (H) were obtained after volume loading and were higher in radiated rats than in control rats. Data are presented as scatter dot plots, with lines showing mean and 95% confidence interval. *P < 0.05 vs. control. †Post hoc test for linear trend P < 0.007.