Fig. 1.

Expression of cardiac fuel metabolism genes. High-fat diet (HFD) promotes an enhanced fatty acid oxidation phenotype in the heart. A and B: no significant difference was observed in short-chain acyl-CoA dehydrogenase (Acads, SCAD) or medium-chain acyl-CoA dehydrogenase (Acadm, MCAD) levels. C–G: significant increases in the mRNA content of long-chain acyl-CoA dehydrogenase (Acadl, LCAD), carnitine palmitoyltransferase 1b (Cpt1b), Cd36, pyruvate dehydrogenase kinase 4 (Pdk4), and peroxisome proliferator-activted receptor-α (Ppara) were observed with HFD feeding, whereas peroxisome proliferator-activated receptor-γ coactivator-1α (Ppargc1a; H) was significantly decreased. Values are expressed as means ± SE; n = 4 per group. P value significance is as shown in the graphs using a two-way Student’s t-test.