Structural properties of the AA and DA from newborn Lox mice. A: genotype, vascular location, and genotype × vascular location had a significant effect on the variance of the mean outer diameter of the pressurized aorta. At all pressures, Lox−/− AA outer diameter was significantly larger than the Lox+/+ AA and Lox−/− DA (*P < 0.05). B: effects of genotype, vascular location, and genotype × vascular location on the aortic compliance varied with applied pressure. Lox−/− AA compliance was significantly lower than the Lox+/+ AA between 30 and 50 mmHg (*P < 0.05). Genotype (&), vascular location (#), or genotype × vascular location (%) accounted for significant variance between groups (P < 0.05). n = 5–8 per group.