Table 1.
Blood and plasma pharmacokinetic parameters in male mice after intravenous and oral administration of GBT1118
| 10 mg/kg iv GBT1118 |
100 mg/kg po GBT1118 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| T½, h | AUC(0-∞), μg·h·ml−1 | Vss, l/kg | CL, ml·min−1·kg−1 | Blood-to-plasma ratio | Tmax, h | Cmax, μg/ml | AUC(0-∞), μg·h·ml−1 | F, % | Blood-to-plasma ratio | |
| Blood | 13.9 | 2,929 | 0.07 | 0.06 | 51.4 | 2 | 318 | 13,428 | 45.8 | 34.1 |
| Plasma | 11.3 | 60 | 2.95 | 3.21 | 8 | 12 | 224 | 33.5 | ||
Blood samples were collected at maximum concentration in plasma (Cmax) after a single intravenous (10 mg/kg) or oral (100 mg/kg) dose of GBT1118. T1/2, terminal half-life; AUC, area under the curve; Vss, volume of distribution; CL, clearance; Tmax, time to reach Cmax; F, bioavailability.