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. 2017 May 4;313(2):L252–L266. doi: 10.1152/ajplung.00453.2016

Fig. 5.

Fig. 5.

CES1- and CYP2D6-deficient PMVECs have increased susceptibility to apoptosis. A: Western blot (WB)for CES1 in control (siCt) or CES siRNA-transfected healthy human PMVECs. B: caspase 3/7 activity assays of siCt and CES1 siRNA-transfected PMVECs at baseline and following METH (5 mM) exposure for 4 h. C and D: WB (C) and caspase 3/7 assay (D) for CYP2D6 in siCt or CYP2D6 (si2D6) siRNA-transfected healthy human PMVECs. Numbers under WB represent densitometry ratio of signal vs. tubulin from 3 independent studies. ***P < 0.001 vs. siCt + METH, ordinary 1-way ANOVA with Tukey’s multiple-comparison test.