Snapshots from cMD simulations of the complex composed of a C2 domain and (a) a pure POPC bilayer; (b, c) a POPC/POPS/PIP2 bilayer; and (d) a POPC/POPS/PIP2/POG bilayer. The PKCα-C2 domain is shown in red, Ca2+ ions in yellow, POPC and POPS in silver, PIP2 in cyan, POG in orange, and phosphorus and nitrogen atoms in POPC (and POPS) are shown in gold and blue, respectively. Solvent molecules were removed for clarity.