Table 2.

Tools for predicting the functional effects of non-synonymous SNPs

Tool	Description	Link	Reference
Auto-Mute 2.0	Sequence-and structure-based	http://binf2.gmu.edu/automute/	[28]
FATHMM	Sequence-based	http://fathmm.biocompute.org.uk/	[29]
MAPP	Sequence-based	http://mendel.stanford.edu/SidowLab/downloads/MAPP/index.html	[30]
Meta-SNP	Consensus classifier	http://snps.biofold.org/meta-snp/	[31]
MuD	Sequence-and structure-based	http://mud.tau.ac.il/	[32]
MutPred	Sequence-based	http://mutpred.mutdb.org/	[33]
PANTHERPSEP	Sequence-based	http://www.pantherdb.org/tools/csnpScoreForm.jsp	[34]
Parepro	Sequence-based	http://www.mobioinfor.cn/parepro/	[35]
PolyPhen-2	Sequence-and structure-based	http://genetics.bwh.harvard.edu/pph2/	[36]
PredictSNP	Consensus classifier	http://loschmidt.chemi.muni.cz/predictsnp/	[37]
Provean	Sequence-and structure-based	http://provean.jcvi.org/index.php	[38]
SIFT	Sequence-based	http://provean.jcvi.org/index.php	[39]
SNAP	Sequence-based	http://www.bio-sof.com/snap	[40]
SNPs&GO	Sequence-and structure-based	http://snps.biofold.org/snps-andgo/snps-and-go.html	[41]
VAPOR	Consensus classifier	https://huma.rubi.ru.ac.za/#vapor	n/a