. Author manuscript; available in PMC: 2018 Jun 1.

Published in final edited form as: Glob Heart. 2017 Mar 13;12(2):151–161. doi: 10.1016/j.gheart.2017.01.009

Table 3.

Tools for predicting changes in stability due to non-synonymous SNPs

Tool	Description	Link	Reference
Auto-Mute 2.0	Sequence-and structure-based	http://binf2.gmu.edu/automute/	[28]
CUPSAT	Structure-based	http://cupsat.tu-bs.de/	[46]
Eris	Structure-based	http://troll.med.unc.edu/eris/login.php	[47]
I-Mutant2.0	Sequence-and structure-based	http://folding.biofold.org/i-mutant/imutant2.0.html	[44]
MuPro	Sequence-and structure-based	http://mupro.proteomics.ics.uci.edu/	[45]
NeEMO	Residue interaction networks	http://protein.bio.unipd.it/neemo/help.html	[48]
PoPMuSiC 2.1	Structure-based	https://soft.dezyme.com/query/create/pop	[49]