Table 2.

Summary results for the penetrance estimates in male and female relatives marginalized by proband’s sex in the simulation (×10⁻²) with censoring rate of 40% or 60%.

			Carriers F̂1(·)					Non-Carriers F̂0(·)
Censor	Relative’s sex	Age	True Risk	Bias	SD	SE	CP	True Risk	Bias	SD	SE	CP
40%	Male	60	16.36	<0.01	1.96	1.96	94.4	11.07	0.05	0.80	0.81	95.9
		65	23.37	0.01	2.59	2.57	94.7	16.05	0.09	0.99	0.99	95.2
		70	31.95	−0.01	3.22	3.20	94.6	22.36	0.12	1.17	1.18	94.1
		75	41.85	−0.04	3.82	3.78	94.1	30.01	0.15	1.38	1.36	94.4
		80	52.59	−0.02	4.28	4.19	93.4	38.84	0.24	1.49	1.51	95.9
	Female	60	21.71	0.32	2.58	2.55	94.3	4.80	−0.06	0.42	0.42	94.4
		65	30.54	0.43	3.29	3.24	94.2	7.07	−0.08	0.57	0.55	93.7
		70	40.94	0.50	3.97	3.88	93.9	10.07	−0.12	0.74	0.72	93.0
		75	52.34	0.52	4.45	4.36	94.4	13.91	−0.16	0.93	0.91	93.2
		80	63.91	0.53	4.69	4.53	93.8	18.67	−0.17	1.12	1.12	94.3
60%	Male	60	16.36	−0.14	2.20	2.18	93.5	11.07	0.17	0.84	0.85	95.0
		65	23.37	−0.21	2.91	2.88	94.0	16.05	0.23	1.04	1.05	95.2
		70	31.95	−0.26	3.63	3.62	94.2	22.36	0.34	1.29	1.27	94.2
		75	41.85	−0.51	4.26	4.31	94.7	30.01	0.30	1.48	1.49	94.6
		80	52.59	−0.98	4.80	4.83	94.3	38.84	0.06	1.76	1.73	94.1
	Female	60	21.71	−0.72	2.79	2.85	94.1	4.80	0.03	0.48	0.48	94.4
		65	30.54	−0.99	3.62	3.68	94.2	7.07	0.04	0.65	0.65	94.9
		70	40.94	−1.21	4.40	4.50	94.5	10.07	0.07	0.85	0.85	94.6
		75	52.34	−1.61	5.02	5.13	94.3	13.91	0.03	1.07	1.08	94.6
		80	63.91	−2.14	5.38	5.46	93.2	18.67	−0.13	1.33	1.33	94.1

Denote the true cumulative risk (True Risk), average estimation bias over 1,000 replications (Bias), empirical standard deviation (SD), average of estimated standard errors from bootstraps (SE), and coverage probability corresponding to nominal 95% confidence intervals (CP). Results are based on 1,000 simulations with sample size n = 2266.