Table 4.

Estimated cumulative risk of Parkinson’s disease onset in LRRK2 carriers and non-carriers in male and female relatives marginalized by proband’s sex and site of enrollment in the Ashkenazi Jewish LRRK2 Consortium study (×10⁻²).

		Carriers F̂1(·)			Non-Carriers F̂0(·)
Relative’s sex	Age	Risk	Lower limit	Upper limit	Risk	Lower limit	Upper limit
Male	60	6.16	2.31	11.22	4.23	2.55	6.44
	65	9.73	3.86	16.80	6.72	4.48	9.70
	70	14.32	5.68	24.50	9.98	6.85	14.16
	75	17.88	7.07	30.78	12.55	8.93	17.13
	80	21.37	8.88	35.67	15.09	10.80	20.50
Female	60	8.41	4.41	13.89	1.77	1.02	2.85
	65	13.20	7.64	20.36	2.83	1.64	4.54
	70	19.23	12.38	27.82	4.25	2.51	6.65
	75	23.82	15.35	34.22	5.39	3.33	8.25
	80	28.23	18.66	40.06	6.54	4.00	10.18

Denote the estimated age-specific risk (Risk) and 95% confidence intervals (Lower limit and Upper limit).