Table 2.
Top 20 pathways associated with language performance.
| Pathway description (Source database) | Sizea | Uncorrected pb |
|---|---|---|
| Netrin-1 signaling (Reactome) | 36 | 2.38E-07 |
| L1CAM interactions (Reactome) | 76 | 9.39E-07 |
| Arrythmogenic right ventricular cardiomyopathy (KEGG) | 71 | 9.78E-07 |
| Ion channel transport (Reactome) | 48 | 5.33E-06 |
| SHH pathway (Biocarta) | 15 | 6.81E-06 |
| Phosphatidylinositol signaling system (KEGG) | 75 | 9.84E-06 |
| Trafficking of AMPA receptors (Reactome) | 26 | 1.17E-05 |
| NRAGE signals death through JNK (Reactome) | 37 | 1.39E-05 |
| Adherens junction (KEGG) | 71 | 1.39E-05 |
| Synthesis of PIPs at the plasma membrane (Reactome) | 28 | 1.59E-05 |
| Integrin cell surface reactions (Reactome) | 74 | 1.72E-05 |
| FC gamma R-mediated phagocytosis (KEGG) | 90 | 4.91E-05 |
| ECM-receptor interaction (KEGG) | 81 | 5.64E-05 |
| Cell death signaling via NGRAGE, NRIF, and NADE (Reactome) | 51 | 7.69E-05 |
| Semaphorin interactions (Reactome) | 61 | 9.89E-05 |
| Hypertrophic cardiomyopathy-HCM (KEGG) | 79 | 1.15E-04 |
| Unblocking of NMDA receptor glutamate binding and activation (Reactome) | 14 | 1.53E-04 |
| Interaction between L1 and Ankyrins (Reactome) | 20 | 1.57E-04 |
| PI metabolism (Reactome) | 44 | 1.59E-04 |
| Glioma (KEGG) | 63 | 1.73E-04 |
a
Number of genes in the pathway.
b
All pathway displayed are significant at false discovery rate (FDR)-corrected p < 0.01.