Table 2.
Odds ratios (ORs) (and 95% CIs) for colorectal adenoma according to rs2720574 polymorphism stratified by calcium/magnesium intake ratio, the Tennessee Colorectal Polyp Studya,b
| SLC7A2 | Adenomas vs Controls | Multiple/advanced adenomas vs Controls | ||||
|---|---|---|---|---|---|---|
|
|
||||||
| rs2720574 | Cases/Controls | OR(95% CI) | P for trend | Cases/Controls | OR(95% CI) | P for trend |
| All subjects | ||||||
| GG | 851/1900 | 1.00 | 365/1900 | 1.00 | ||
| GC/CC | 481/968 | 1.09(0.94,1.26) | 224/968 | 1.20(0.98,1.46) | ||
| GC | 408/835 | 1.10(0.94,1.28) | 189/835 | 1.22(0.99,1.50) | ||
| CC | 73/133 | 1.16(0.83,1.62) | 0.26 | 35/133 | 1.39(0.90,2.15) | 0.07 |
| Calcium/magnesium intake ratio ≤ 2.78 | ||||||
| GG | 451/909 | 1.00 | 190/909 | 1.00 | ||
| GC/CC | 297/435 | 1.36(1.11,1.68) | 146/435 | 1.68(1.28,2.20) | ||
| GC | 254/369 | 1.37(1.11,1.69) | 127/369 | 1.71(1.29,2.26) | ||
| CC | 43/66 | 1.24(0.78,1.97) | 0.01 | 19/66 | 1.57(0.85,2.92) | 0.001 |
| Calcium/magnesium intake ratio > 2.78 | ||||||
| GG | 400/991 | 1.00 | 175/991 | 1.00 | ||
| GC/CC | 184/533 | 0.84(0.67,1.04) | 78/533 | 0.78(0.57,1.06) | ||
| GC | 154/466 | 0.85(0.67,1.06) | 62/466 | 0.76(0.54,1.05) | ||
| CC | 30/67 | 1.12(0.69,1.82) | 0.25 | 16/67 | 1.34(0.72,2.49) | 0.38 |
| P for interactionc | 0.002 | 0.0001 | ||||
a
Phase I +Phase II
b
Unconditional logistic regression models adjusting for age (continuous), sex, race (white, others), education (categorical), recruitment sites, body mass index (categorical), smoking status (former, current, never), alcohol drinking status (former, current, never), physical activity (yes, no), daily intakes of total energy, calcium and magnesium (continuous).
c
Interactions for genetic polymorphism with calcium/magnesium intakes ratio (continuous).