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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Semin Cell Dev Biol. 2017 Jun 1;69:9–17. doi: 10.1016/j.semcdb.2017.05.020

Figure 3. MACF1 in neurite outgrowth.

Figure 3

(A) MACF1 regulation of neurite outgrowth. MACF1 localizes near the distal ends of growing axons and dendrites, where it stabilizes microtubule bundles and leads to the assembly of polymerized actin. In the absence of MACF1, microtubules and actin are disorganized and unstable at the neurite tip and scattered in the cytosol. (B) GSK-3 regulates the activity of MACF1 in dendrite outgrowth and arborization. When MACF1 is phosphorylated by GSK-3, it results in multiple short primary dendrites. When MACF1 remains unphosphorylated, neurons extend a single long primary dendrite.