Figure 1.

Scheme of the different interacting proteins and functions of CHI3L1. Receptors for CHI3L1 are not known, but interactions are reported for syndecan-1/integrin β1, RAGE-S100A9 and IL13Rα2 and activated pathways comprise STAT3, NF-κB, ERK1/2, MAPK, AKT which are involved in angiogenesis, proliferation, survival and invasion.