Table 1.
Plasma pharmacokinetic parameters of AS in sham and CS rats
| AUC0–∞h (μg h/mL) | MRT (h) | CLtot (mL/h) | V ss (mL) | K el (h−1) | T 1/2 (h) | T max (h) | C max (μg/mL) | |
|---|---|---|---|---|---|---|---|---|
| Sham-AS | 32.9 ± 1.5 | 2.1 ± 0.0 | 84.4 ± 4.2 | 219 ± 41 | 0.80 ± 0.03 | 0.88 ± 0.04 | 1.83 ± 0.33 | 10.1 ± 0.4 |
| C-AS | 36.0 ± 1.3* | 2.6 ± 0.2* | 78.6 ± 3.4 | 244 ± 28 | 0.49 ± 0.02* | 1.37 ± 0.03* | 2.70 ± 0.11 * | 10.3 ± 0.3 |
Values are presented as the mean ± SEM (n = 3–6)
AUC area under the concentration–time curve, MRT mean residence time, CL tot total body clearance, V ss steady-state volume of distribution, K el elimination rate constant, T 1/2 biological half-life, T max time to maximum drug concentration, C max maximum drug concentration, AS astragaloside-IV, CS crush syndrome
*p < 0.05 versus sham-AS group analyzed by Student’s t test