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. 2017 Aug 31;4:137. doi: 10.3389/fmed.2017.00137

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Copyright © 2017 De Re, Magris and Cannizzaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tissue transglutaminase 2 (TG2) enzymatic activity. TG2 is a ubiquitously expressed member of the TG family of enzymes that all catalyze Ca²⁺-dependent protein deamidation or transamidation (cross-linking) of glutamine residues.