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. 2017 Aug 31;8:219. doi: 10.3389/fendo.2017.00219

Table 6.

Dual energy X-ray absorptiometry bone parameters in women.

Age (yr) 40–44 (n = 28) 45–49 (n = 32) 50–54 (n = 30) 55–59 (n = 31) 60–64 (n = 31) 65–69 (n = 33) 70–74 (n = 30) 75+ (n = 34) β-Coefficient (95% CI) R2 Unadjusted p-value β-Coefficient (95% CI) R2 Adjusted p-value

Whole body
aBMD (g/cm2) 1.1 ± 0.1(n=27) 1.1 ± 0.1 1.0 ± 0.1 1.0 ± 0.1(n=30) 1.0 ± 0.1 0.9 ± 0.1 0.9 ± 0.1(n=29) 0.9 ± 0.1(n=30) −0.005 (−0.006, −0.005) 0.37 <0.0001 −0.004 (−0.005, −0.003) 0.54 <0.0001
BMC (g) 2,273 ± 361(n=27) 2,210 ± 366 2,081 ± 449 1,827 ± 300(n=30) 1,752 ± 252 1,749 ± 369 1,679 ± 368(n=29) 1,538 ± 303(n=30) −18.9 (−22.5, −15.3) 0.31 <0.0001 −10.6 (−12.9, −8.2) 0.75 <0.0001
BA (cm2) 2,025 ± 193(n=27) 2,041 ± 229 1,974 ± 250 1,840 ± 201(n=30) 1,820 ± 165 1,839 ± 241 1,781 ± 231(n=29) 1,703 ± 227(n=30) −8.7 (−11.0, −6.5) 0.20 <0.0001 −−2.8 (−4.0, −1.7) 0.83 <0.0001
Spine
aBMD (g/cm2) 1.1 ± 0.1(n=27) 1.0 ± 0.1 0.9 ± 0.2 0.8 ± 0.1(n=30) 0.8 ± 0.1 0.8 ± 0.2(n=32) 0.8 ± 0.1(n=29) 0.7 ± 0.1(n=31) −0.008 (−0.01, −0.007) 0.34 <0.0001 −0.006 (−0.008, −0.005) 0.50 <0.0001
BMC (g) 53.3 ± 9.5(n=27) 48.7 ± 10.1 45.5 ± 10.1 37.6 ± 8.1(n=30) 38.2 ± 7.2 37.6 ± 10.2(n=32) 35.7 ± 9.2(n=29) 32.9 ± 8.5(n=31) −0.5 (−0.6, −0.4) 0.29 <0.0001 −0.3 (−0.4, −0.2) 0.58 <0.0001
BA (cm2) 48.6 ± 3.6(n=27) 48.5 ± 4.9 48.5 ± 4.4 46.4 ± 5.4(n=30) 46.9 ± 4.3 47.7 ± 5.2(n=32) 45.6 ± 5.1(n=29) 44.9 ± 6.1(n=31) −0.1 (−0.2, −0.1) 0.07 <0.0001 −0.007 (−0.05, 0.03) 0.47 0.734
Total hip
aBMD (g/cm2) 1.0 ± 0.2(n=27) 1.0 ± 0.1(n=30) 0.9 ± 0.1 0.8 ± 0.1(n=30) 0.8 ± 0.1(n=29) 0.7 ± 0.1(n=32) 0.7 ± 0.1(n=29) 0.7 ± 0.1(n=33) −0.009 (−0.01, −0.008) 0.44 <0.0001 −0.008 (−0.009, −0.006) 0.51 <0.0001
BMC (g) 28.6 ± 5.0(n=27) 28.1 ± 4.8(n=30) 25.0 ± 4.5 23.0 ± 3.3(n=30) 22.0 ± 3.2(n=29) 21.9 ± 3.6(n=32) 20.9 ± 4.4(n=29) 19.2 ± 3.9(n=33) −0.2 (−0.3, −0.2) 0.35 <0.0001 −0.2 (−0.2, −0.1) 0.51 <0.0001
BA (cm2) 28.3 ± 2.1(n=27) 28.5 ± 1.9(n=30) 28.8 ± 2.1 28.3 ± 2.0(n=30) 28.5 ± 1.9(n=29) 29.6 ± 2.3(n=32) 28.4 ± 2.3(n=29) 28.6 ± 2.3(n=33) 0.004 (−0.02, 0.03) 0.0005 0.719 0.04 (0.02, 0.06) 0.39 <0.0001
Femoral neck
aBMD (g/cm2) 1.0 ± 0.1(n=27) 1.0 ± 0.1(n=30) 0.9 ± 0.1 0.8 ± 0.1(n=30) 0.8 ± 0.1(n=29) 0.7 ± 0.1(n=32) 0.7 ± 0.1(n=29) 0.7 ± 0.1(n=32) −0.008 (−0.01, −0.007) 0.45 <0.0001 −0.007 (−0.008, −0.006) 0.54 <0.0001
BMC (g) 4.1 ± 0.8(n=27) 4.0 ± 0.8(n=30) 3.6 ± 0.8 3.3 ± 0.7(n=30) 3.2 ± 0.6(n=29) 3.1 ± 0.7(n=32) 3.0 ± 0.7(n=29) 2.6 ± 0.7(n=32) −0.04 (−0.04, −0.03) 0.29 <0.0001 −0.03 (−0.03, −0.02) 0.44 <0.0001
BA (cm2) 4.2 ± 0.7(n=27) 4.1 ± 0.6(n=30) 4.2 ± 0.6 4.1 ± 0.7(n=30) 4.1 ± 0.6(n=29) 4.2 ± 0.7(n=32) 4.2 ± 0.6(n=29) 3.9 ± 0.7(n=32) −0.005 (−0.01, 0.002) 0.01 0.124 0.001 (−0.006, 0.008) 0.14 0.775
Radius
aBMD (g/cm2) 0.6 ± 0.1(n=27) 0.6 ± 0.1 0.6 ± 0.1 0.5 ± 0.1(n=29) 0.5 ± 0.1 0.4 ± 0.1 0.5 ± 0.1 0.4 ± 0.1(n=32) −0.006 (−0.007, −0.005) 0.44 <0.0001 −0.005 (−0.005, −0.004) 0.58 <0.0001
BMC (g) 9.0 ± 1.5(n=27) 8.8 ± 1.2 8.3 ± 1.8 7.0 ± 1.2(n=29) 7.1 ± 1.3 6.8 ± 1.6 6.6 ± 1.4 6.1 ± 1.2(n=32) −0.08 (−0.09, −0.06) 0.31 <0.0001 −0.05 (−0.06, −0.04) 0.60 <0.0001
BA (cm2) 14.5 ± 1.3(n=27) 15.0 ± 1.7 14.7 ± 1.8 14.8 ± 1.5(n=29) 15.0 ± 1.6 15.6 ± 1.2 14.7 ± 1.5 15.3 ± 1.9(n=32) 0.01 (−0.003, 0.03) 0.01 0.103 0.04 (0.03, 0.05) 0.41 <0.0001

Values are mean ± SD.

Bold indicates significance.

Adjustments were made for weight and height.

β-Coefficients are calculated with age as a continuous variable.

Superscript values indicate the group numbers.

aBMD, areal bone mineral density; BMC, bone mineral content; BA, bone area.