Table 8.
Peripheral quantitative computed tomography bone parameters in women.
| Age (yr) | 40–44 (n = 28) | 45–49 (n = 32) | 50–54 (n = 30) | 55–59 (n = 31) | 60–64 (n = 31) | 65–69 (n = 33) | 70–74 (n = 30) | 75+ (n = 34) | β-Coefficient (95% CI) | R2 | Unadjusted p-value | β-Coefficient (95% CI) | R2 | Adjusted p-value |
| Radius | ||||||||||||||
| 4% Total vBMD (mg/cm3) | 305.9 ± 46.1(n=25) | 294.0 ± 47.3(n=30) | 267.7 ± 45.5(n=26) | 245.0 ± 34.9(n=25) | 244.9 ± 43.6(n=25) | 214.7 ± 42.8(n=29) | 236.0 ± 39.1(n=22) | 208.1 ± 39.1(n=30) | −2.57 (−3.0, −2.1) | 0.36 | <0.0001 | −2.31 (−2.8, −1.8) | 0.41 | <0.0001 |
| 4% Trab.vBMD (mg/cm3) | 146.5 ± 37.0(n=25) | 144.5 ± 33.8(n=30) | 122.3 ± 30.3(n=26) | 114.4 ± 27.9(n=25) | 106.5 ± 21.0(n=25) | 97.8 ± 30.8(n=29) | 104.0 ± 16.8(n=22) | 83.9 ± 29.9(n=30) | −1.63 (−1.9, −1.3) | 0.33 | <0.0001 | −1.52 (−1.9, −1.2) | 0.35 | <0.0001 |
| 33% Ct.vBMD (mg/cm3) | 1,252.2 ± 39.8(n=26) | 1,235.8 ± 46.4(n=29) | 1,208.3 ± 52.8(n=28) | 1,169.4 ± 46.6(n=27) | 1,150.3 ± 35.7(n=25) | 1,142.9 ± 52.5(n=28) | 1,154.0 ± 37.5(n=22) | 1,131.5 ± 45.5(n=25) | −3.28 (−3.8, −2.7) | 0.42 | <0.0001 | −3.03 (−3.6, −2.5) | 0.45 | <0.0001 |
| 33% CSA (mm2) | 104.8 ± 11.9(n=26) | 109.0 ± 11.7(n=29) | 108.8 ± 16.6(n=28) | 108.9 ± 17.1(n=27) | 109.6 ± 11.7(n=25) | 111.0 ± 11.7(n=28) | 105.5 ± 13.0(n=22) | 115.6 ± 16.7(n=25) | 0.18 (0.02, 0.3) | 0.02 | 0.027 | 0.33 (0.2, 0.5) | 0.23 | <0.0001 |
| 33% Ct.Th (mm) | 2.4 ± 0.3(n=26) | 2.3 ± 0.3(n=29) | 2.2 ± 0.4(n=28) | 1.8 ± 0.3(n=27) | 1.8 ± 0.3(n=25) | 1.7 ± 0.4(n=28) | 1.7 ± 0.4(n=22) | 1.5 ± 0.3(n=25) | −0.02 (−0.03, −0.02) | 0.43 | <0.0001 | −0.02 (−0.02, −0.02) | 0.50 | <0.0001 |
| 33% SSI (mm3) | 215.5 ± 37.4(n=26) | 222.7 ± 34.8(n=29) | 211.6 ± 53.3(n=28) | 189.0 ± 37.1(n=27) | 194.4 ± 34.5(n=25) | 193.7 ± 126.2(n=28) | 185.8 ± 33.3(n=22) | 191.0 ± 43.1(n=25) | −0.89 (−1.3, −0.4) | 0.07 | <0.0001 | −0.39 (−0.8, 0.01) | 0.29 | 0.06 |
| Tibia | ||||||||||||||
| 4% Total vBMD (mg/cm3) | 290.1 ± 36.0(n=26) | 276.5 ± 38.9(n=30) | 255.5 ± 36.8(n=30) | 225.5 ± 29.4(n=28) | 224.2 ± 30.4(n=27) | 201.1 ± 35.5(n=31) | 206.6 ± 38.2(n=25) | 187.2 ± 36.7(n=31) | −2.72 (−3.1, −2.3) | 0.47 | <0.0001 | −2.5 (−2.9, −2.1) | 0.55 | <0.0001 |
| 4% Trab.vBMD (mg/cm3) | 195.5 ± 28.6(n=26) | 186.3 ± 33.6(n=30) | 163.9 ± 32.0(n=30) | 141.0 ± 32.1(n=28) | 139.5 ± 25.5(n=27) | 133.8 ± 34.0(n=31) | 137.6 ± 30.9(n=25) | 119.0 ± 31.6(n=31) | −1.90 (−2.2, −1.57) | 0.35 | <0.0001 | −1.65 (−2.0, −1.3) | 0.43 | <0.0001 |
| 38% Ct.vBMD (mg/cm3) | 1,234.9 ± 43.4(n=26) | 1,215.1 ± 49.9(n=30) | 1,197.3 ± 46.2(n=30) | 1,161.8 ± 44.8(n=28) | 1,145.0 ± 49.0(n=27) | 1,144.4 ± 53.8(n=31) | 1,147.7 ± 47.0(n=25) | 1,128.2 ± 55.3(n=31) | −2.64 (−3.2, −2.1) | 0.29 | <0.0001 | −2.45 (−3.0, −1.9) | 0.31 | <0.0001 |
| 38% CSA (mm2) | 362.0 ± 49.7(n=26) | 363.2 ± 43.1(n=30) | 355.5 ± 48.5(n=30) | 363.8 ± 43.5(n=28) | 359.1 ± 35.7(n=27) | 373.8 ± 56.5(n=31) | 334.5 ± 46.4(n=25) | 360.4 ± 52.7(n=31) | −0.16 (−0.7, 0.3) | 0.01 | 0.530 | 0.48 (−0.001, 1.0) | 0.22 | 0.050 |
| 38% Ct.Th (mm) | 4.1 ± 0.6(n=26) | 4.0 ± 0.6(n=30) | 3.9 ± 0.4(n=30) | 3.7 ± 0.5(n=28) | 3.5 ± 0.6(n=27) | 3.6 ± 0.7(n=31) | 3.3 ± 0.7(n=25) | 3.0 ± 0.6(n=31) | −0.03 (−0.03, −0.02) | 0.23 | <0.0001 | −0.02 (−0.03, −0.01) | 0.33 | <0.0001 |
| 38% SSI (mm3) | 1,430.8 ± 271.2(n=26) | 1,359.2 ± 226.1(n=30) | 1,353.3 ± 283.8(n=30) | 1,350.1 ± 224.8(n=28) | 1,244.8 ± 146.2(n=27) | 1,338.9 ± 313.4(n=31) | 1,134.5 ± 250.5(n=25) | 1,175.1 ± 227.5(n=31) | −6.34 (−9.0, −3.7) | 0.09 | <0.0001 | −2.55 (−5.0, −0.1) | 0.34 | 0.038 |
Values are mean ± SD.
Bold indicates significance.
Adjustments were made for weight and height.
β-Coefficients are calculated with age as a continuous variable.
Superscript values indicate the group numbers.
vBMD, volumetric bone mineral density; Trab, trabecular; Ct, cortical; Th, thickness; CSA, cross-sectional area; SSI, stress strain index.