Table 4.
C-reactive protein (CRP), high-sensitivity C-reactive protein (hsCRP), and arterial stiffness.
| Study population | Findings | Reference |
|---|---|---|
| 100 patients with metabolic syndrome, 14 controls | There was a significant correlation between aortic flow propagation velocity (AVP), FMD (flow-mediated dilatation), and high CRP, indicating a possible link between aortic stiffness, endothelial dysfunction, and inflammation | Adel et al. (7) |
| 150 renal transplant recipients | High (> 20 mg/L) post-transplant CRP levels predicted pulse wave velocity (PWV) and cardiovascular morbidity in a two-year time period after renal transplantation | Gurlek Demirci et al. (102) |
| 40 patients with type 2 diabetes mellitus | hsCRP showed a moderate positive correlation with arterial stiffness in patients with type 2 diabetes mellitus | Nurizal et al. (104) |
| 825 men (mean age: 74 years) | Arterial stiffness was found to correlate positively with circulating levels of CRP | McEniery et al. (100) |
| 362 middle-aged and elderly men | Low-grade inflammation was shown to be independently related to increase of aortic artery stiffness over and above traditional risk factors and atherosclerosis | Nakhai-Pour et al. (43) |
| 77 patients with rheumatoid arthritis (RA) and 142 healthy individuals | Median aortic PWV was significantly higher in RA patients than in control subjects and correlated independently with age, mean arterial pressure, and CRP | Mäki-Petäjä et al. (21) |
| 214 asymptomatic subjects with a mean age of 59 years | CRP was related to measures of arterial wave reflection and stiffness in asymptomatic subjects | Kullo et al. (99) |
| 866 participants above 55 years | Levels of CRP were linearly associated with PWV | Mattace-Raso et al. (98) |
| 2,668 Japanese men (43 ± 10 years old) | PWV showed a significant correlation with the logarithm of hsCRP, but multiple linear regression analyses demonstrated that the logarithm of hsCRP was not significantly related to PWV, independent from conventional risk factors | Tomiyama et al. (101) |
| 158 apparently healthy subjects (age range 40–65 years) | Plasma levels of hsCRP were positively correlated with AIx, central pulse pressure and central systolic blood pressure | Kampus et al. (103) |