Table 2.
Multivariate Analysis of Breast Cancer-specific Survival (BCSS) and Overall Survival (OS) Predictors Using a Cox Proportional Hazards Model.
| Variables | BCSS | OS | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Histological type | ||||
| IDC-L versus IDC | 1.00 (0.96 to 1.05) | 0.837 | 0.93 (0.90 to 0.97) | <0.001 |
| IDC-L versus ILC | 0.99 (0.93 to 1.06) | 0.814 | 1.00 (0.95 to 1.05) | 0.970 |
| Year of diagnosis | ||||
| 1998–2002 | 1.24 (1.20 to 1.27) | <0.001 | 1.22 (1.20 to 1.25) | <0.001 |
| 2003–2007 | Reference | |||
| Age at diagnosis | ||||
| ≤50 y | 0.89 (0.87 to 0.91) | <0.001 | 0.56 (0.55 to 0.58) | <0.001 |
| >50 y | Reference | |||
| Race | ||||
| Black | 1.30 (1.26 to 1.35) | <0.001 | 1.28 (1.24 to 1.32) | <0.001 |
| Othersa | 0.87 (0.83 to 0.92) | <0.001 | 0.81 (0.78 to 0.84) | <0.001 |
| White | Reference | |||
| Marital status | ||||
| Married | 0.82 (0.80 to 0.84) | <0.001 | 0.69 (0.67 to 0.70) | <0.001 |
| Unmarriedb | Reference | |||
| Grade | ||||
| 1 | 0.50 (0.47 to 0.53) | <0.001 | 0. 28 (0.80 to 0.85) | <0.001 |
| 2 | Reference | |||
| 3 and UDc | 1.47 (1.43 to 1.52) | <0.001 | 1.23 (1.20 to 1.26) | <0.001 |
| Tumor size (cm) | ||||
| <2 | 0.49 (0.48 to 0.51) | <0.001 | 0.64 (0.62 to 0.65) | <0.001 |
| 2–5 | Reference | |||
| >5 | 1.55 (1.49 to 1.60) | <0.001 | 1.49 (1.45 to 1.54) | <0.001 |
| Positive nodes | ||||
| 0 | 0.29 (0.28 to 0.30) | <0.001 | 0.42 (0.41 to 0.44) | <0.001 |
| 1–3 | 0.57 (0.54 to 0.59) | <0.001 | 0.60 (0.59 to 0.62) | <0.001 |
| 4–9 | Reference | |||
| ≥10 | 1.34 (1.29 to 1.40) | <0.001 | 1.40 (1.35 to 1.45) | <0.001 |
| ER status | ||||
| Negative | 1.36 (1.31 to 1.41) | <0.001 | 1.19 (1.15 to 1.22) | <0.001 |
| Positive | Reference | |||
| PR status | ||||
| Negative | 1.37 (1.32 to 1.42) | <0.001 | 1.23 (1.20 to 1.27) | <0.001 |
| Positive | Reference | |||
| Radiation | ||||
| No | 1.16 (1.13 to 1.20) | <0.001 | 1.29 (1.26 to 1.32) | <0.001 |
| Yes | Reference | |||
| Surgery type | ||||
| No | 1.42 (1.32 to 1.54) | <0.001 | 1.34 (1.25 to 1.44) | <0.001 |
| Lumpectomy | 0.85 (0.82 to 0.87) | <0.001 | 0.87 (0.85 to 0.89) | <0.001 |
| Mastectomy | Reference | |||
Note:
aIncluding American Indian/Alaskan native, Asian/Pacific Islander, and others-unspecified.
bIncluding divorced, separated, single (never married), and widowed.
cIncluding grade 3 and undifferentiated.
Abbreviations: BCSS: breast cancer-specific survival; OS: overall survival; HR: hazard ratio; CI: confidence interval; IDC-L: invasive ductal carcinoma with lobular features; IDC: invasive ductal carcinoma; ILC: invasive lobular carcinoma; ER: estrogen receptor; PR: progesterone receptor.