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. 2017 Sep 4;7:10393. doi: 10.1038/s41598-017-10927-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell proliferation and collagen III, fibronectin accumulation along with upregulated MDM2 expression in high glucose-cultured GMCs. (A) BrdU summarized data showing that high glucose induces HBZY-1 cell proliferation from 6 h to 24 h n = 7. (B) Representative western blot images and (C) summarized data showing the collagen III and fibronectin protein level in HBZY-1 treated with high glucose for indicated time n ≥ 3. (D) Representative western blot images and (E) summarized data showing MDM2 protein level in HBZY-1 treated with high glucose for indicated time n = 6. Ctrl: control; HG: high glucose. ^* P < 0.05 vs. Ctrl.