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. 2017 Sep 4;7:10393. doi: 10.1038/s41598-017-10927-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic depletion of MDM2 attenuates high glucose-induced collagen III, fibronectin accumulation and cell proliferation in GMCs. (A) Representative western blot images and (B) summarized data showing the interfere effect of three different sequence siRNA oligonucleotides targeting MDM2 n = 3. (C) Representative western blot images and (D) summarized data showing that depletion MDM2 by siRNA partially attenuates collagen III and fibronectin accumulation in high glucose-stimulated HBZY-1 cells n = 6. (E) BrdU summarized data showing that high glucose-induced cell proliferation is inhibited by MDM2 genetic depletion n = 6. Scra: scramble shRNA; siMDM2: MDM2 siRNA. ^* P < 0.05 vs. Ctrl + Scra; ^# P < 0.05 vs. HG + Scra.