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. 2017 Sep 4;7:10393. doi: 10.1038/s41598-017-10927-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nutlin-3a cannot ameliorate the renal impairment in STZ-induced diabetic mice. (A) Representative photomicrograph of p53 density in the glomeruli of mice in each group (original magnification 200x). (B) Quantification of p53-positive cells/glomerular cross section for each group n = 6. (C–J) Summarized data showing the serum glucose, body weight, Kw/Bw, serum albumin, serum creatinine, blood urea nitrogen, urine total protein, and UACR of the experimental mice in our study n ≥ 7. (K) Representative PAS staining images of glomeruli (original magnification 200x). (L) Summarized data showing the glomerular damage index (GDI) of the three groups of mice. n ≥ 7. Vehl: vehicle; Kw: kidney weight; Bw: bodyweight; UACR: urine albumin to creatinine ratio. ^* P < 0.05 vs. Ctrl mice; ^** P < 0.01 vs. Ctrl mice; ^*** P < 0.0001 vs. Ctrl mice; ^# P > 0.05 vs. Ctrl mice; ^### P > 0.05 vs. diabetic mice + Vehl; ^& P > 0.05 vs. diabetic mice + Vehl.