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. 2017 Sep 4;7:10393. doi: 10.1038/s41598-017-10927-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Numb expression is upregulated by high glucose simulation in GMCs and not affected by MDM2 inhibition. (A) Representative western blot images and (B) summarized data showing the Numb protein level in HBZY-1 with high glucose treatment at indicated time points n = 6. ^* P < 0.05 vs. Ctrl. (C) Representative western blot images and (D) summarized data showing that the abundance of Numb is not influenced by MDM2 inhibition n = 6. ^* P < 0.05 vs. Ctrl + Scra; ^& P > 0.05 vs. HG + Scra.