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. 2017 Aug 31;10:273. doi: 10.3389/fnmol.2017.00273

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Copyright © 2017 Phamluong, Darcq, Wu, Sakhai and Ron.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dopamine D2 receptor stimulation does not alter Fyn activation or GluN2B phosphorylation. Quinpirole (QP; 5 mg/kg) or saline was systemically administered (i.p.). The DMS (A,D), DLS (B,E), and NAc (C,F) were collected 15 min after drug administration. The level of Tyr420[Fyn] phosphorylation (pFyn) (upper panels), Fyn (middle panels) (A–C), Tyr1472[GluN2B] phosphorylation (pGluN2B, top panels), GluN2B (middle panels) (D–F) were measured by western blot analysis. The immunoreactivity of GAPDH (bottom panels) was used as a loading control (bottom panel). Data are presented as the mean densitometry value of the phosphorylated protein divided by the mean densitometry values of the total protein ± SEM and expressed as % of vehicle. Two-tailed t-test. n = 5–6 mice per treatment group.