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. 2017 Aug 31;8:592. doi: 10.3389/fphys.2017.00592

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Copyright © 2017 Zubcevic, Santisteban, Perez, Arocha, Hiller, Malphurs, Colon-Perez, Sharma, de Kloet, Krause, Febo and Raizada.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of systemic Ang II injection on the brain. (A) A single I.P. injection of Ang II caused a marked increase in the manganese-enhanced signal, corresponding to neuronal activation, in several nuclei of the forebrain and hindbrain as measured by MEMRI 24 h following Ang II injection (right panel) and compared to saline injection (left panel) (averaged from n = 6 per group). The brain segmentation slices are arranged consequentially from the brainstem regions (bottom left segment) through to the hypothalamic PVN region (bottom right segment). (B) Map of brain regions as per Paxinos-Watson.